منابع مشابه
PWS and Obesity, and PWS look-alikes
Obesity is a common finding in our general population, the proportion of obese individuals having increased at an alarming rate all over the world in the past 20 years. Compared to growth failure, obesity is rare in a population of individuals with a genetic syndrome. One database for genetic syndromes, Online Mendelian Inheritance in Man, contains 169 matches for obesity and 421 matches for gr...
متن کاملInfertility in Pws
A better word is infertile....the word “sterile” has negative connotations. On a purely theoretical level, males with PWS should be able to correct their infertility if they receive gonadotropin replacement or if we knew of a way to restore endogenous gonadotropin secretion. The testicles are generally normal (except in cases of testicular damage due to maldescent and/or surgical damage) Howeve...
متن کاملTranslational neuroscience approaches to hyperphagia.
Introduction 1Food intake in humans and other mammals is a complex process, resulting from the integration of homeostatic systems that monitor energy stores with hedonic drive resulting from the behaviorally reinforcing properties of food (Fig. 1) (Lutter and Nestler, 2009). Under conditions of food scarcity, the hedonic and homeostatic drives cooperate to enhance the intake of highly palatable...
متن کاملRFC 5994 Eth PWs to MPLS Transport
Ethernet pseudowires are widely deployed to support packet transport of Ethernet services. These services in-turn provide transport for a variety of client networks, e.g., IP and MPLS. This document uses procedures defined in the existing IETF specifications of Ethernet pseudowires carried over MPLS networks. Many of the requirements for the services provided by the mechanisms explained in this...
متن کاملPrader-Willi Syndrome (PWS) — Diagnosis and Treatment
Prader-Willi syndrome (PWS) is an unusual, rare complex autosomal neurodevelopmental disease resulting from genomic imprinting and uniparental disomy of maternal chromosome 15 with a simultaneous functional loss of the parental part 15q11.2-q13. This article briefly elucidates the phenomenon of genomic imprinting, focuses on the diverse clinical features of PWS and concludes with the management...
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ژورنال
عنوان ژورنال: Nature Reviews Endocrinology
سال: 2018
ISSN: 1759-5029,1759-5037
DOI: 10.1038/nrendo.2018.19